Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.64 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | LYN | P07948 | 2/20 | 0.48 |
| ▸ | TNF | P01375 | 2/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | MUSK | O15146 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306029 | 0.93 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4305259 | 0.92 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4307774 | 0.86 | MAPK13 (0.70) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4303736 | 0.84 | BRAF (0.62) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL13852786 | 0.84 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4303704 | 0.81 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL13296803 | 0.81 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4306959 | 0.81 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL1409878 | 0.79 | MAPK13 (0.69) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL12245427 | 0.78 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131437-A1 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | CORIUM INTERNATIONAL, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| EP-1838700-A2 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | Novartis AG (CH) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072589-A2 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131437-A1 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | UCK2, ULK2, MAP3K1 | MAPK14 133/4885MAPK13 103/4885MAPK12 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.