Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.77 |
| ▸ | PPARA | Q07869 | 7/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 2/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979692 | 0.87 | PPARG (1.00) | PPARGPPARA | |
| SCHEMBL979691 | 0.73 | PPARG (0.63) | PPARGPPARATSHRCYP2C19KLK7 | |
| SCHEMBL10688303 | 0.73 | FFAR1 (0.55) | PPARGPPARATSHRSLC6A4HAO1 | |
| SCHEMBL28850896 | 0.72 | TSHR (0.61) | PPARGPPARATSHRKLK7CRHBP | |
| SCHEMBL17964196 | 0.72 | CYP2C19 (0.56) | PPARGPPARACYP2C19KDM4E | |
| SCHEMBL19999148 | 0.72 | CYP2C19 (0.56) | PPARGPPARACYP2C19KDM4E | |
| SCHEMBL11032151 | 0.72 | CYP2C19 (0.56) | PPARGPPARACYP2C19KDM4E | |
| SCHEMBL11428660 | 0.72 | PPARG (0.49) | PPARGPPARACYP2C19 | |
| SCHEMBL28948579 | 0.71 | CYP2C19 (0.54) | PPARGPPARACYP2C19KDM4E | |
| SCHEMBL4301066 | 0.71 | PPARG (0.78) | PPARGPPARATSHRSLC6A4KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125711-A1 | 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | Albireo Ab (SE) | 2009-12-02 | — | — | EP | claimed |
| WO-2008108735-A1 | 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | ALBIREO AB (SE) | 2008-09-12 | — | — | WO | claimed |
| EP-2125711-A1 | 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | Albireo Ab (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008108735-A1 | 2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | ALBIREO AB (SE) | 2008-09-12 | — | — | WO | disclosed |