Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | TPH1 | P17752 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014369 | 0.90 | NPC1 (0.55) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL4304299 | 0.81 | S1PR1 (0.48) | S1PR1S1PR3S1PR5TPH1NPC1 | |
| SCHEMBL1015459 | 0.79 | S1PR1 (0.60) | S1PR1S1PR3CYP2C9 | |
| SCHEMBL11983603 | 0.77 | S1PR1 (0.70) | S1PR1S1PR3NPC1RAB9AMAPT | |
| SCHEMBL4311124 | 0.71 | S1PR1 (0.52) | S1PR1S1PR3CYP2C9 | |
| SCHEMBL11904389 | 0.71 | S1PR1 (0.52) | S1PR1S1PR3CYP2C9 | |
| SCHEMBL1015235 | 0.69 | RAB9A (0.42) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL1071506 | 0.68 | S1PR1 (0.61) | S1PR1S1PR3S1PR5CYP2C9 | |
| SCHEMBL11983819 | 0.68 | S1PR1 (0.61) | S1PR1S1PR3S1PR5CYP2C9 | |
| SCHEMBL1014383 | 0.68 | RAB9A (0.46) | S1PR1S1PR3NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133136-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |