Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.61 |
| ▸ | GAA | P10253 | 7/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | GLA | P06280 | 2/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | CASP7 | P55210 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | XDH | P47989 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924237 | 0.88 | KDM4E (0.63) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL9064595 | 0.86 | KDM4E (0.61) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL5161494 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL13993933 | 0.83 | CA12 (0.52) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL2663753 | 0.83 | GAA (0.74) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL11071838 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL31440687 | 0.81 | GAA (0.71) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL750862 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL642672 | 0.81 | GAA (0.71) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL204027 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582719-B1 | Carboxylic-acid-terminated hyperbranched poly(benzoxazole) and the star block copolymers therefrom | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 2009-09-01 | — | — | US | disclosed |
| US-20090118233-A1 | Heterocyclic compounds having inhibitory activity against HIV integrase | MURAI HITOSHI | 2009-05-07 | — | — | US | disclosed |
| EP-2045242-A1 | Heterocyclic compounds having inhibitory activity against HIV integrase | Shionogi&Co., Ltd. (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7358249-B2 | Heterocyclic compounds having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2008-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118233-A1 | Heterocyclic compounds having inhibitory activity against HIV integrase | CYP3A7, CDK7, CYP2A7 | KDM4E 1722/4885ALDH1A1 381/4885GAA 1549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.