Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.53 |
| ▸ | GRM5 | P41594 | 10/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003764 | 0.93 | GRM1 (0.58) | GRM1GRM5PDE10APDK4CDK9 | |
| SCHEMBL4009123 | 0.90 | PDE10A (0.53) | GRM1GRM5PDE10APDK4SCN9A | |
| SCHEMBL4014744 | 0.90 | GRM1 (0.56) | GRM1GRM5PDE10APDK4CDK9 | |
| SCHEMBL4013686 | 0.89 | GRM1 (0.58) | GRM1GRM5PDE10APDK4CDK9 | |
| SCHEMBL13769472 | 0.89 | GRM1 (0.54) | GRM1GRM5PDE10APDK4CDK9 | |
| SCHEMBL4009648 | 0.88 | CCNT1 (0.46) | PDE10ACDK9CCNT1HTR1ASLC6A2 | |
| SCHEMBL4013425 | 0.88 | PDE10A (0.62) | GRM1GRM5PDE10APDK4 | |
| SCHEMBL4013818 | 0.85 | PDE10A (0.55) | GRM1GRM5PDE10APDK4CDK9 | |
| SCHEMBL13769766 | 0.85 | PDE10A (0.55) | GRM1GRM5PDE10APDK4CDK9 | |
| SCHEMBL17001926 | 0.84 | PDK4 (0.59) | GRM1GRM5PDE10APDK4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |