Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304270 | 0.88 | CYP1A2 (0.43) | CYP1A2CYP2C19LMNAALDH1A1KDM4E | |
| SCHEMBL4304995 | 0.85 | CYP1A2 (0.43) | CYP1A2CYP2C19LMNAALDH1A1KDM4E | |
| SCHEMBL4306365 | 0.80 | LMNA (0.45) | LMNAALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL4302849 | 0.76 | MCL1 (0.35) | CYP1A2CYP2C19LMNAALDH1A1KDM4E | |
| SCHEMBL4305020 | 0.75 | LMNA (0.46) | CYP1A2CYP2C19LMNAALDH1A1KDM4E | |
| SCHEMBL4306380 | 0.74 | CYP1A2 (0.43) | CYP1A2CYP2C19LMNAALDH1A1KDM4E | |
| SCHEMBL29406512 | 0.73 | ABL1 (0.61) | LMNAALDH1A1KDM4ERXFP1ABL1 | |
| SCHEMBL29752578 | 0.73 | ABL1 (0.61) | LMNAALDH1A1KDM4ERXFP1ABL1 | |
| SCHEMBL26661413 | 0.73 | ABL1 (0.61) | LMNAALDH1A1KDM4ERXFP1ABL1 | |
| SCHEMBL2452734 | 0.73 | ABL1 (0.61) | LMNAALDH1A1KDM4ERXFP1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |