5-Fluoronicotinic Acid

5-Fluoronicotinic Acid

SCHEMBL430582

O=C(O)c1cncc(F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 6/20 1.00
ALDH1A1 P00352 4/20 0.57
KDM4E B2RXH2 3/20 0.57
MEN1 O00255 3/20 0.57
KMT2A Q03164 3/20 0.57
POLB P06746 1/20 0.57
LMNA P02545 1/20 0.57
DDO Q99489 1/20 0.57
HCAR1 Q9BXC0 1/20 0.48
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
MKNK1 Q9BUB5 1/20 0.46
MKNK2 Q9HBH9 1/20 0.46
APP P05067 1/20 0.43
GAA P10253 1/20 0.43
HCAR3 P49019 1/20 0.43
MYC P01106 1/20 0.42
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
BCL2L1 Q07817 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-Fluoronicotinic Acid SCHEMBL29951819 1.00 HCAR2 (1.00) HCAR2ALDH1A1KDM4EMEN1KMT2A
5-Fluoronicotinic Acid SCHEMBL29235098 0.98 HCAR2 (0.96) HCAR2ALDH1A1KDM4EMEN1KMT2A
5-Fluoronicotinic Acid SCHEMBL27617092 0.98 HCAR2 (0.96) HCAR2ALDH1A1KDM4EMEN1KMT2A
SCHEMBL51830 0.83 HCAR2 (0.70) HCAR2ALDH1A1KDM4EMEN1KMT2A
Bromide SCHEMBL21332093 0.80 HCAR2 (0.67) HCAR2ALDH1A1KDM4EMEN1KMT2A
SCHEMBL19987838 0.80 HCAR2 (0.67) HCAR2ALDH1A1KDM4EMEN1KMT2A
Hydrochloric Acid SCHEMBL7124062 0.80 HCAR2 (0.67) HCAR2ALDH1A1KDM4EMEN1KMT2A
Fluoride SCHEMBL21331909 0.80 HCAR2 (0.67) HCAR2ALDH1A1KDM4EMEN1KMT2A
Hydrochloric Acid SCHEMBL7661020 0.80 HCAR2 (0.67) HCAR2ALDH1A1KDM4EMEN1KMT2A
Hydrochloric Acid SCHEMBL1117746 0.80 HCAR2 (0.67) HCAR2ALDH1A1KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 456 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025056008-A1 PYRIPYROPENE DERIVATIVE, AND COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 2025-03-20 WO claimed
CN-115279730-B 2, 5-Or 2, 6-disubstituted hydroquinone derivatives having at least one carboxyl, sulfo or amido group, useful as medicaments OM药物公司 2025-02-14 CN claimed
CN-111295382-B Bridged bicyclic compounds as farnesyl ester X receptor modulators 百时美施贵宝公司 2024-02-02 CN claimed
CN-116987064-B Preparation method and application of pyrimidine bisnicotinamide derivative 宁夏佰斯特医药化工有限公司 2024-01-26 CN claimed
CN-115073363-B 5-fluoro-2-methoxy nicotinaldehyde and preparation method thereof 宁波申泰生物科技有限公司 2024-01-26 CN claimed
CN-114181179-B Compound containing naphthoquinone oxime structure and medical application of compound as bombesin receptor subtype-3 agonist 上海交通大学 2023-11-24 CN claimed
CN-116987064-A Preparation method and application of pyrimidine bisnicotinamide derivative 宁夏佰斯特医药化工有限公司 2023-11-03 CN claimed
CN-111511731-B Olefin compounds as modulators of the farnesol X receptor 百时美施贵宝公司 2023-05-23 CN claimed
CN-114181179-A Compound containing naphthoquinone oxime structure and medical application of compound as bombesin receptor subtype-3 agonist 上海交通大学 2022-03-15 CN claimed
CN-109212051-B Gas chromatography-mass spectrometry combined method for determining nine trace amounts of halogenated nicotinic acid in drinking water 丁立平 2021-11-19 CN claimed
CN-107903209-B Synthetic method of 2-amino-5-fluoropyridine-3-methyl formate 宁夏忠同生物科技有限公司 2021-05-14 CN claimed
CN-111162313-A Polymer electrolyte and lithium ion battery 珠海冠宇电池有限公司 2020-05-15 CN claimed
CN-109212051-A The gas chromatography-mass spectrometry of nine kinds of halogenated niacin of trace in a kind of measurement drinking water 丁立平 2019-01-15 CN claimed
EP-2129672-B1 AZAADAMANTANE ESTER AND CARBAMATE DERIVATIVES AND METHODS OF USE THEREOF ABBOTT LAB (US) 2011-05-18 EP claimed
CN-100355733-C Industrialized method for preparing 2-chlorine-5-fluorin-nicotinic aicd YAOMINGKANGDE NEW MEDICINE DEV (CN) 2007-12-19 CN claimed
CN-1626519-A Industrialized method for preparing 2-chlorine-5-fluorin-nicotinic aicd YAOMINGKANGDE NEW MEDICINE DEV (CN) 2005-06-15 CN claimed
US-4851535-A 2-(5-FLUORONICOTINOYL)ACETIC ACID DERIVATIVES, ANTIBACTERIAL 1-ARYL-1,4-DIHYDRO-4-OXONAPHTHYRIDINES TOYAMA CHEMICAL CO., LTD. (JP) 1989-07-25 US claimed
JP-61171469-A None JP disclosed
US-4383851-A CONTROLLING WILD OATS IN WHEAT THE DOW CHEMICAL COMPANY (US) 1983-05-17 US disclosed
US-4309431-A INHIBITING MULTIPLE MYELOMA WITH ACRONYCINE ELI LILLY AND COMPANY (US) 1982-01-05 US disclosed