⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoromethane SCHEMBL27956378 | 0.89 | — | — | |
| SCHEMBL28270198 | 0.87 | — | — | |
| SCHEMBL6822598 | 0.78 | — | — | |
| SCHEMBL106130 | 0.76 | — | — | |
| SCHEMBL3414996 | 0.74 | — | — | |
| SCHEMBL8507132 | 0.74 | — | — | |
| SCHEMBL3866736 | 0.74 | HTT (0.31) | — | |
| SCHEMBL4781828 | 0.70 | — | — | |
| SCHEMBL8505360 | 0.70 | — | — | |
| SCHEMBL6819409 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120025235-A | Industrial preparation method of sevoflurane | 江苏恒瑞医药股份有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-119039100-A | Preparation method of sevoflurane | 江苏恒瑞医药股份有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-119019217-A | Refining method of sevoflurane | 江苏恒瑞医药股份有限公司 | 2024-11-26 | — | — | CN | claimed |
| CN-118184493-A | Method for preparing sevoflurane by continuous gas phase method | 风火轮(上海)生物科技有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-108689808-B | Preparation method of chloromethyl hexafluoroisopropyl ether | 江苏恒瑞医药股份有限公司 | 2021-11-16 | — | — | CN | claimed |
| CN-108727166-B | Refining method of chloromethyl hexafluoroisopropyl ether | 江苏恒瑞医药股份有限公司 | 2021-06-29 | — | — | CN | claimed |
| CN-108727166-A | A kind of process for purification of chloromethyl hexafluoro isopropyl ether | 江苏恒瑞医药股份有限公司 | 2018-11-02 | — | — | CN | claimed |
| CN-108689808-A | A kind of preparation method of chloromethyl hexafluoro isopropyl ether | 江苏恒瑞医药股份有限公司 | 2018-10-23 | — | — | CN | claimed |
| CN-106966874-A | A kind of synthetic method of Sevoflurane | 临海市利民化工有限公司 | 2017-07-21 | — | — | CN | claimed |
| CN-106220479-A | A kind of method recycling Sevoflurane impurity F (1) | 鲁南制药集团股份有限公司 | 2016-12-14 | — | — | CN | claimed |
| CN-103934020-B | Eight Guanoctines replaced are as the application of the synthetic catalyst of methyl fluoride hexafluoroisopropyl ether and process for catalytic synthesis | FUJIAN BOTE CHEMICAL PRODUCT CO., LTD. (CN) | 2016-03-30 | — | — | CN | claimed |
| CN-103934020-A | Use of octa-substituted guazatine as synthesis catalyst of fluoromethyl hexafluoro isopropyl ether and catalytic synthesis method | FUJIAN BOTE CHEMICAL PRODUCT CO LTD | 2014-07-23 | — | — | CN | claimed |
| CN-121717691-A | Synthesis method of sevoflurane | 鲁南制药集团股份有限公司 | 2026-03-24 | — | — | CN | disclosed |
| CN-120025235-B | Industrial preparation method of sevoflurane | 江苏恒瑞医药股份有限公司 | 2025-09-09 | — | — | CN | disclosed |
| CN-120025235-A | Industrial preparation method of sevoflurane | 江苏恒瑞医药股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| CN-120025235-A | Industrial preparation method of sevoflurane | 江苏恒瑞医药股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| US-RE35568-E | Method for fluorodecarboxylation | OHMEDA PHARMACEUTICAL PRODUCTS DIVISION INC. (US) | 1997-07-22 | — | — | US | disclosed |
| EP-0437689-B1 | A method for fluorodecarboxylation | OHMEDA PHARMA PROD (US) | 1995-09-27 | — | — | EP | disclosed |
| EP-0437689-A1 | A method for fluorodecarboxylation | Ohmeda Pharmaceutical Products Division Inc. (US) | 1991-07-24 | — | — | EP | disclosed |
| US-4996371-A | Reacting halogenated aliphatic carboxylic acids with bromine trifluoride | BOC, INC. (US) | 1991-02-26 | — | — | US | disclosed |