Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 8/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.49 |
| ▸ | PDE4A | P27815 | 12/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561893 | 0.88 | ADORA2B (0.58) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL4314446 | 0.81 | ADORA2A (0.44) | ADORA2A | |
| SCHEMBL561996 | 0.81 | ADORA2A (0.64) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL562941 | 0.81 | ADORA2B (0.63) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL562556 | 0.78 | ADORA2B (0.59) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL10184866 | 0.78 | ADORA2B (0.59) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL563329 | 0.78 | ADORA2B (0.59) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL563241 | 0.78 | ADORA2B (0.58) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL562533 | 0.78 | ADORA2B (0.58) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL562577 | 0.77 | ADORA2B (0.57) | ADORA2BADORA2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044074-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | Incyte Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007150025-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |