Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALPL | P05186 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ACR | P10323 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4305120 | 0.98 | KMT2A (0.46) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL4302712 | 0.94 | KMT2A (0.47) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL16270147 | 0.82 | KMT2A (0.49) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL4305117 | 0.82 | KMT2A (0.41) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL22574774 | 0.80 | MAPT (0.49) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL3261535 | 0.79 | ALPL (0.54) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL16445052 | 0.78 | MAPT (0.50) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL5725305 | 0.76 | HCAR2 (0.45) | KMT2AMAPTL3MBTL1TP53NPSR1 | |
| SCHEMBL1455903 | 0.75 | MAPT (0.47) | KMT2AALPLMAPTRAB9ANPC1 | |
| SCHEMBL27258762 | 0.75 | ALPL (0.47) | KMT2AALPLMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |