Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420814 | 0.88 | BACE1 (0.35) | SLC9A1 | |
| SCHEMBL4309373 | 0.83 | ABL1 (0.36) | CCR2 | |
| SCHEMBL1421023 | 0.78 | BACE1 (0.38) | SLC9A1CCR2 | |
| SCHEMBL3179429 | 0.78 | BACE1 (0.33) | — | |
| SCHEMBL1421247 | 0.77 | RAB9A (0.36) | CCR2 | |
| SCHEMBL4310210 | 0.75 | BACE1 (0.38) | CCR2 | |
| SCHEMBL1424309 | 0.73 | ABL1 (0.36) | — | |
| SCHEMBL1420855 | 0.71 | HCRTR1 (0.36) | — | |
| SCHEMBL4314819 | 0.71 | AKR1B1 (0.35) | — | |
| SCHEMBL4313717 | 0.71 | BACE1 (0.36) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134617-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 2009-11-05 | — | — | WO | disclosed |