Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626230 | 0.92 | EGLN1 (0.58) | EGLN1HRH4HRH3VEGFAFLT1 | |
| SCHEMBL4310730 | 0.77 | EGLN1 (0.65) | EGLN1HRH4HRH3 | |
| SCHEMBL4303657 | 0.75 | CNR2 (0.46) | EGLN1ALDH1A1TP53CNR2 | |
| SCHEMBL17154105 | 0.74 | EGLN1 (0.72) | EGLN1HRH4HRH3HSD17B10ALDH1A1 | |
| SCHEMBL4303666 | 0.74 | EGLN1 (1.00) | EGLN1HRH4HRH3KDM4EMEN1 | |
| SCHEMBL4309470 | 0.74 | EGLN1 (1.00) | EGLN1HRH4HRH3 | |
| SCHEMBL4310717 | 0.71 | EGLN1 (1.00) | EGLN1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL4307360 | 0.71 | EGLN1 (0.67) | EGLN1KDRRAB9AKMT2ACNR2 | |
| SCHEMBL4302325 | 0.71 | EGLN1 (0.66) | EGLN1RAB9AKDM4EMEN1ALDH1A1 | |
| SCHEMBL4304488 | 0.70 | EGLN1 (0.62) | EGLN1RAB9AKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134754-A1 | BENZOIMIDAZOLE GLYCINAMIDES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-05 | — | — | WO | disclosed |