Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.72 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25853279 | 0.86 | PIN1 (0.64) | EGLN1PIN1SMN1; SMN2HRH4HRH3 | |
| SCHEMBL4303666 | 0.84 | EGLN1 (1.00) | EGLN1PIN1HRH4HRH3ALDH1A1 | |
| SCHEMBL4310717 | 0.83 | EGLN1 (1.00) | EGLN1POLBALDH1A1KMT2AMMP13 | |
| SCHEMBL4307360 | 0.80 | EGLN1 (0.67) | EGLN1SMN1; SMN2KMT2A | |
| SCHEMBL4302325 | 0.80 | EGLN1 (0.66) | EGLN1SMN1; SMN2USP2POLBALDH1A1 | |
| SCHEMBL5509574 | 0.79 | PIN1 (1.00) | PIN1SMN1; SMN2HRH4HSD17B10TP53 | |
| SCHEMBL17154106 | 0.79 | EGLN1 (0.55) | EGLN1PIN1SMN1; SMN2ALDH1A1MMP13 | |
| SCHEMBL4310730 | 0.79 | EGLN1 (0.65) | EGLN1HRH4HRH3MMP13 | |
| SCHEMBL4309470 | 0.78 | EGLN1 (1.00) | EGLN1HRH4HRH3GAA | |
| SCHEMBL25764927 | 0.78 | PIN1 (0.64) | EGLN1PIN1SMN1; SMN2HRH4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150284335-A1 | Benzoimidazoles as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284335-A1 | Benzoimidazoles as prolyl hydroxylase inhibitors | EGLN3, EGLN2, P4HA1 | EGLN1 5/4885PIN1 83/4885SMN1; SMN2 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.