Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318405 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAALMNAKMT2AL3MBTL1 | |
| SCHEMBL5402848 | 0.82 | GAA (0.50) | ALDH1A1GAALMNAKMT2AL3MBTL1 | |
| SCHEMBL13892809 | 0.81 | ALDH1A1 (0.49) | ALDH1A1GAALMNAKMT2AL3MBTL1 | |
| SCHEMBL23879242 | 0.78 | GAA (0.56) | ALDH1A1GAALMNAKMT2ACES2 | |
| SCHEMBL30452479 | 0.78 | GAA (0.56) | ALDH1A1GAALMNAKMT2ACES2 | |
| SCHEMBL4311022 | 0.75 | S1PR3 (0.34) | ALDH1A1GAAKMT2ACES2CES1 | |
| SCHEMBL5395211 | 0.70 | ALDH1A1 (0.86) | ALDH1A1GAALMNAKMT2AL3MBTL1 | |
| SCHEMBL23879249 | 0.70 | ALDH1A1 (0.46) | ALDH1A1GAALMNAKMT2AL3MBTL1 | |
| SCHEMBL23879235 | 0.69 | ALDH1A1 (1.00) | ALDH1A1GAALMNAL3MBTL1RIPK1 | |
| SCHEMBL30452940 | 0.69 | ALDH1A1 (1.00) | ALDH1A1GAALMNAL3MBTL1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| EP-1963314-A2 | P38 KINASE INHIBITING AGENTS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067478-A2 | P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007067478-A2 | P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MAPK1, MAPK8, MAPK7 | ALDH1A1 1400/4885GAA 1757/4885LMNA 4285/4885 |
| US-20070129372-A1 | P38 kinase inhibiting agents | MAPK1, MAPK8, MAPK7 | ALDH1A1 1400/4885GAA 1757/4885LMNA 4285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.