Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15649747 | 0.79 | CYP1A2 (0.51) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL21258976 | 0.73 | MAPT (0.72) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL5257148 | 0.71 | NPC1 (0.49) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL10495840 | 0.71 | MAPT (0.62) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL14428206 | 0.70 | KMT2A (0.55) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL3871509 | 0.70 | JAK2 (0.52) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL3574120 | 0.69 | SCN9A (0.54) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL23413086 | 0.69 | RAB9A (0.51) | MAPTMEN1KMT2ARAB9ATSHR | |
| SCHEMBL2409063 | 0.69 | MAPT (0.62) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL2859978 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074113-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NeuroSearch A/S (DK) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008040753-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2008-04-10 | — | — | WO | disclosed |