Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.51 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306740 | 0.90 | KMT2A (0.59) | HRH3AVPR1BKDM4EALDH1A1KMT2A | |
| SCHEMBL8022961 | 0.82 | NPC1 (0.45) | KDM4EALDH1A1KMT2A | |
| SCHEMBL4304235 | 0.79 | MAPT (0.37) | KDM4EALDH1A1KMT2A | |
| SCHEMBL4319272 | 0.78 | LMNA (0.41) | KDM4EALDH1A1KMT2A | |
| SCHEMBL8012975 | 0.77 | HCRTR1 (0.45) | AVPR1BALDH1A1 | |
| SCHEMBL4306365 | 0.77 | LMNA (0.45) | KDM4EALDH1A1KMT2A | |
| SCHEMBL4302782 | 0.76 | STS (0.43) | KDM4E | |
| SCHEMBL4311073 | 0.76 | HCRTR1 (0.44) | HRH3AVPR1BALDH1A1 | |
| SCHEMBL2089343 | 0.75 | KDM4E (0.68) | HRH3KDM4EALDH1A1KMT2AESR1 | |
| SCHEMBL4311066 | 0.74 | AVPR1B (0.41) | HRH3AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |