Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621564 | 0.83 | CRBN (0.40) | LMNAALDH1A1L3MBTL1GBA1NPC1 | |
| SCHEMBL9820818 | 0.82 | GBA1 (0.41) | LMNAALDH1A1L3MBTL1GBA1NAAA | |
| SCHEMBL9820748 | 0.82 | GBA1 (0.41) | LMNAALDH1A1L3MBTL1GBA1NAAA | |
| SCHEMBL9820784 | 0.82 | GBA1 (0.41) | LMNAALDH1A1L3MBTL1GBA1NAAA | |
| SCHEMBL9670978 | 0.82 | GBA1 (0.41) | LMNAALDH1A1L3MBTL1GBA1NAAA | |
| SCHEMBL9820839 | 0.82 | GBA1 (0.41) | LMNAALDH1A1L3MBTL1GBA1NAAA | |
| SCHEMBL9670725 | 0.79 | CRBN (0.43) | LMNAGBA1NPC1 | |
| SCHEMBL20183036 | 0.79 | — | — | |
| SCHEMBL11509552 | 0.77 | CRBN (0.38) | LMNAGBA1NPC1 | |
| SCHEMBL896961 | 0.75 | GBA1 (0.41) | LMNAALDH1A1GBA1NAAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639878-A | Acyloxylation process for preparing 4-acyloxy-2-azetidinone derivatives | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 1997-06-17 | — | — | US | claimed |
| EP-0372699-B1 | Process for the preparation of 4-acyloxy-2-azetidinone derivatives | SUNTORY LTD (JP) | 1995-02-22 | — | — | EP | claimed |
| US-5026844-A | Process for the preparation of 4-acyloxy-2-azetidinone derivatives | SUNTORY LIMITED (JP) | 1991-06-25 | — | — | US | claimed |
| EP-0404585-A2 | Process for the preparation of 4-acyloxyazetidin-2-one by singlet oxygen oxidation | MERCK & CO. INC. (US) | 1990-12-27 | — | — | EP | claimed |
| US-4940520-A | Process for the preparation of 4-acyloxyazetidin-2-one by singlet oxygen oxidation | MERCK & CO., INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0372699-A1 | Process for the preparation of 4-acyloxy-2-azetidinone derivatives | SUNTORY LIMITED (JP) | 1990-06-13 | — | — | EP | claimed |
| US-4683303-A | Reduction process for the preparation of 4-unsubstituted azetidin-2-ones | PFAENDLER HANS R (DE) | 1987-07-28 | — | — | US | claimed |
| JP-2172970-A | — | — | None | — | — | JP | disclosed |
| JP-6009551-A | — | — | None | — | — | JP | disclosed |
| CN-101462995-B | Method for preparing 4-alkynyl azetidin-2-one | SHANGHAI INST ORGANIC CHEM | 2011-08-10 | — | — | CN | disclosed |
| CN-101462995-A | Method for preparing 4-alkynyl azetidin-2-one | SHANGHAI INST ORGANIC CHEM (CN) | 2009-06-24 | — | — | CN | disclosed |
| WO-2009015179-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| EP-0638552-B1 | PROCESS FOR SYNTHESIZING 4-SUBSTITUTED AZETIDINONE DERIVATIVE | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2003-06-04 | — | — | EP | disclosed |
| EP-0372699-A1 | Process for the preparation of 4-acyloxy-2-azetidinone derivatives | SUNTORY LIMITED (JP) | 1990-06-13 | — | — | EP | disclosed |
| EP-0372699-A1 | Process for the preparation of 4-acyloxy-2-azetidinone derivatives | SUNTORY LIMITED (JP) | 1990-06-13 | — | — | EP | disclosed |
| US-4923982-A | Oxidation and reduction method to produce 4-acyloxyazetidin-2-one | MERCK & CO., INC. (US) | 1990-05-08 | — | — | US | disclosed |
| US-4683226-A | BACTERICIDES | SCHERING CORPORATION (US) | 1987-07-28 | — | — | US | disclosed |
| US-4683303-A | Reduction process for the preparation of 4-unsubstituted azetidin-2-ones | PFAENDLER HANS R (DE) | 1987-07-28 | — | — | US | disclosed |
| US-4448782-A | BACTERICIDES | SCHERING CORPORATION (US) | 1984-05-15 | — | — | US | disclosed |
| US-4423055-A | 6-Substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids | SCHERING CORPORATION (US) | 1983-12-27 | — | — | US | disclosed |