Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820818 | 1.00 | GBA1 (0.41) | GBA1CRBNPOLBKMT2ANOS1 | |
| SCHEMBL9820748 | 1.00 | GBA1 (0.41) | GBA1CRBNPOLBKMT2ANOS1 | |
| SCHEMBL9820839 | 1.00 | GBA1 (0.41) | GBA1CRBNPOLBKMT2ANOS1 | |
| SCHEMBL9820784 | 1.00 | GBA1 (0.41) | GBA1CRBNPOLBKMT2ANOS1 | |
| SCHEMBL9621564 | 0.98 | CRBN (0.40) | GBA1CRBNPOLBKMT2ANOS1 | |
| SCHEMBL9670725 | 0.95 | CRBN (0.43) | GBA1CRBNPOLBKMT2ANOS1 | |
| SCHEMBL9621737 | 0.87 | GAA (0.37) | CRBNPOLBKMT2ALMNAALDH1A1 | |
| SCHEMBL11509552 | 0.85 | CRBN (0.38) | GBA1CRBNPOLBKMT2ALMNA | |
| SCHEMBL4310403 | 0.82 | LMNA (0.41) | GBA1LMNAALDH1A1L3MBTL1NAAA | |
| SCHEMBL525863 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229566-B1 | 1-BENZENE SULFONYL 2-OXO-5-ALKOXY PYRROLIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINE AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-05-06 | — | — | EP | disclosed |
| EP-0296979-B1 | 1-BENZOYL-2-OXO-5-ALKOXY-PYRROLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PREPARATIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-12-04 | — | — | EP | disclosed |
| EP-0296978-B1 | 1-BENZYL 2-OXO 5-ALKOXY PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDICINES | ROUSSEL-UCLAF (FR) | 1991-09-11 | — | — | EP | disclosed |
| US-4948804-A | TREATING PSYCHOLOGICAL DISORDERS | ROUSSEL UCLAF (FR) | 1990-08-14 | — | — | US | disclosed |
| US-4882350-A | TREATMENT OF INTELLECTUAL OR NERVOUS ASTHENIAS, MEMORY FAILURES | ROUSSEL UCLAF (FR) | 1989-11-21 | — | — | US | disclosed |
| US-4829079-A | AMNESIA | ROUSSEL UCLAF (FR) | 1989-05-09 | — | — | US | disclosed |
| EP-0296979-A2 | 1-Benzoyl-2-oxo-5-alkoxy-pyrrolidine derivatives, their preparation, their use and preparations containing them | ROUSSEL-UCLAF (FR) | 1988-12-28 | — | — | EP | disclosed |
| EP-0296978-A2 | 1-Benzyl 2-oxo 5-alkoxy pyrrolidine derivatives, process for their preparation, compositions containing them and their use in medicines | ROUSSEL-UCLAF (FR) | 1988-12-28 | — | — | EP | disclosed |
| EP-0229566-A2 | 1-Benzene sulfonyl 2-oxo-5-alkoxy pyrrolidines, process for their preparation, their use as medicine and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-07-22 | — | — | EP | disclosed |