Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 20/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9946539 | 1.00 | CETP (0.47) | CETPNR1I2KCNH2 | |
| SCHEMBL9946508 | 0.89 | CETP (0.44) | CETPNR1I2KCNH2 | |
| SCHEMBL1506521 | 0.88 | CETP (0.59) | CETPNR1I2KCNH2 | |
| SCHEMBL4317579 | 0.87 | CETP (0.59) | CETPNR1I2KCNH2 | |
| SCHEMBL9946547 | 0.83 | CETP (0.61) | CETPNR1I2 | |
| SCHEMBL4312583 | 0.83 | CETP (0.61) | CETPNR1I2 | |
| SCHEMBL4310140 | 0.82 | CETP (0.48) | CETPNR1I2KCNH2 | |
| SCHEMBL9946528 | 0.82 | CETP (0.36) | CETPKCNH2 | |
| SCHEMBL4307420 | 0.80 | CETP (0.62) | CETPNR1I2KCNH2 | |
| SCHEMBL14471022 | 0.79 | CETP (0.41) | CETPNR1I2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865707-B2 | Cholesteryl ester transfer protein inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20090018054-A1 | Cholesteryl Ester Transfer Protein Inhibitors | MERCK SHARP & DOHME LLC | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018054-A1 | Cholesteryl Ester Transfer Protein Inhibitors | CETP, APOB, MTTP | CETP 1/4885NR1I2 107/4885KCNH2 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.