Secologanin

Secologanin

SCHEMBL431171

C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC=O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 16/20 0.55
▸ MEN1 O00255 1/20 0.54
▸ MAPT P10636 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ POLB P06746 1/20 0.53
▸ CTDSP1 Q9GZU7 1/20 0.53
▸ ELANE P08246 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28663748 0.91 STAT3 (0.55) STAT3MEN1MAPTKMT2APOLB
SCHEMBL31006406 0.89 STAT3 (0.55) STAT3MEN1MAPTKMT2APOLB
SCHEMBL2135809 0.89 STAT3 (0.52) STAT3MEN1MAPTKMT2APOLB
SCHEMBL2135813 0.89 STAT3 (0.52) STAT3MEN1MAPTKMT2APOLB
SCHEMBL29629350 0.88 POLB (0.49) STAT3MEN1MAPTKMT2APOLB
SCHEMBL29391273 0.88 POLB (0.49) STAT3MEN1MAPTKMT2APOLB
SCHEMBL29425864 0.87 STAT3 (0.64) STAT3MAPT
SCHEMBL29425794 0.86 STAT3 (0.57) STAT3MEN1MAPTKMT2APOLB
SCHEMBL29425822 0.86 POLB (0.47) STAT3MEN1MAPTKMT2APOLB
Secologanin SCHEMBL21358657 0.84 POLB (0.43) STAT3MEN1MAPTKMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 411 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4379068-B1 IRIDOID OR SECO-IRIDOID DERIVATIVES AND THEIR USE IN A TANNING PROCESS INSTITUT NAT DES SCIENCES APPLIQUEES DE ROUEN (FR) 2025-06-04 — — EP claimed
EP-4526426-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS Danmarks Tekniske Universitet (DK) 2025-03-26 — — EP claimed
EP-4520348-A1 CARBON CHAIN SUBSTANCE FOR REGULATING TRANSMEMBRANE TRANSPORT AND FLUIDITY OF CELL MEMBRANES, AND PREPARATION AND USE THEREOF Sunforest (Beijing) Biopharma Ltd (CN) 2025-03-12 — — EP claimed
WO-2024168348-A1 PRODUCTION OF MONOTERPENE INDOLE ALKALOID COMPOUNDS IN A HETEROLOGOUS HOST TRYPTAGENIX, INC. (US) 2024-08-15 — — WO claimed
US-20240254533-A1 METHODS FOR PRODUCING TRYPTAMINE DERIVATIVES OCTARINE BIO APS (DK) 2024-08-01 — — US claimed
EP-4379068-A1 IRIDOID OR SECO-IRIDOID DERIVATIVES AND THEIR USE IN A TANNING PROCESS Institut National Des Sciences Appliquées De Rouen (FR) 2024-06-05 — — EP claimed
EP-4347856-A2 METHODS FOR PRODUCING TRYPTAMINE DERIVATIVES Octarine Bio ApS (DK) 2024-04-10 — — EP claimed
US-20240017234-A1 IMPROVED MICROCAPSULES AND METHOD FOR THE PRODUCTION AND USE THEREOF Follman GmbH & Co. KG (DE) 2024-01-18 — — US claimed
WO-2023222879-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS DANMARKS TEKNISKE UNIVERSITET (DK) 2023-11-23 — — WO claimed
CN-115792070-A Method for measuring content of iridoid component in honeysuckle oral liquid 真奥金银花药业有限公司 2023-03-14 — — CN claimed
EP-2001877-A1 METHOD FOR EXTRACTING TARGET ALKALOID USING AN IONIC LIQUID AS EXTRACTING SOLVENT Bioniqs Limited (GB) 2008-12-17 — — EP claimed
WO-2008050916-A1 OLEANANE TRITERPENE SAPONIN COMPOUNDS WHICH ARE EFFECTIVE ON TREATMENT OF DEMENTIA AND MILD COGNITIVE IMPAIRMENT(MCI), AND IMPROVEMENT OF COGNITIVE FUNCTION SK CHEMICALS CO., LTD. (KR) 2008-05-02 — — WO claimed
WO-2007146841-A2 COLLAGEN CROSS-LINKING AGENTS ON DENTAL RESTORATIVE TREATMENT AND PREVENTIVE DENTISTRY THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2007-12-21 — — WO claimed
WO-2007110637-A1 METHOD FOR EXTRACTING TARGET ALKALOID USING AN IONIC LIQUID AS EXTRACTING SOLVENT BIONIQS LIMITED (GB) 2007-10-04 — — WO claimed
EP-1548006-B1 Synthesis of tetraazapentamethine derivatives, keratin fibers dyeing process which uses such synthesis OREAL (FR) 2007-09-05 — — EP claimed
US-20050198744-A1 Applying 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-N-methylpyridinium chloride and an oxidizing agent, developing the desired coloration L'OREAL S.A. (FR) 2005-09-15 — — US claimed
EP-1548006-A1 Synthesis of tetraazapentamethine derivatives, keratin fibers dyeing process which uses such synthesis L'OREAL (FR) 2005-06-29 — — EP claimed
WO-2000042200-A1 STRICTOSIDINE GLUCOSIDASE FROM CATHARANTHUS ROSEUS AND ITS USE IN ALKALOID PRODUCTION UNIVERSITEIT LEIDEN (NL) 2000-07-20 — — WO claimed
EP-0156267-B1 METHOD FOR THE PREPARATION OF STRICTOZIDIN GYOGYNÖVENY KUTATO INTEZET (HU) 1989-08-30 — — EP claimed
EP-0156267-A2 Method for the preparation of strictozidin GYOGYNÖVENY KUTATO INTEZET (HU) 1985-10-02 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050198744-A1 Applying 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-N-methylpyridinium chloride and an oxidizing agent, developing the desired coloration KRT18, TPM4, AZI2 STAT3 3542/4885MEN1 3246/4885MAPT 721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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