Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947531 | 0.80 | — | — | |
| SCHEMBL7632368 | 0.79 | CHRM3 (0.40) | TSHRCRHBPCRHR2LMNAHSD17B10 | |
| Bicarbonate SCHEMBL11493509 | 0.74 | CHRM3 (0.37) | TSHRCRHBPCRHR2LMNAHSD17B10 | |
| Methyl Benzoate SCHEMBL28154074 | 0.72 | TSHR (0.76) | TSHRLMNAALDH1A1MAPTTDP1 | |
| SCHEMBL28013731 | 0.71 | CYP3A4 (0.57) | TSHRLMNAHSD17B10ALDH1A1CFTR | |
| SCHEMBL10484531 | 0.71 | TSHR (0.67) | TSHRALDH1A1MAPTTDP1POLB | |
| SCHEMBL9340188 | 0.71 | TSHR (0.67) | TSHRALDH1A1MAPTTDP1POLB | |
| Acetic Acid Methyl Ester SCHEMBL19208995 | 0.69 | TDP1 (0.55) | TSHRLMNAHSD17B10ALDH1A1MAPT | |
| SCHEMBL10484479 | 0.68 | TSHR (0.57) | TSHRLMNAALDH1A1MAPTTDP1 | |
| SCHEMBL1417759 | 0.68 | LMNA (0.52) | TSHRLMNAHSD17B10ALDH1A1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264608-A1 | METHOD FOR PRODUCING NORBORNENE BASED ADDITION (CO)POLYMER | NIHON UNIVERSITY (JP) | 2009-10-22 | — | — | US | disclosed |
| EP-2033978-A1 | Method for producing norbornene based addition (co)polymer | Nihon University (JP) | 2009-03-11 | — | — | EP | disclosed |
| EP-1826221-A1 | METHOD FOR PRODUCING NORBORNENE BASED ADDITION (CO)POLYMER | Nihon University (JP) | 2007-08-29 | — | — | EP | disclosed |