Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 15/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.35 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398312 | 0.89 | TNK2 (0.46) | TNK2FGFR2FGFR1IGF1R | |
| SCHEMBL3030306 | 0.88 | TNK2 (0.34) | TNK2FGFR2FGFR1 | |
| SCHEMBL3030193 | 0.88 | TNK2 (0.34) | TNK2FGFR2FGFR1 | |
| SCHEMBL3030190 | 0.88 | TNK2 (0.34) | TNK2FGFR2FGFR1 | |
| SCHEMBL13961844 | 0.86 | TNK2 (0.46) | TNK2FGFR2FGFR1IGF1R | |
| SCHEMBL4316054 | 0.85 | TNK2 (0.48) | TNK2FGFR2FGFR1IGF1R | |
| SCHEMBL402101 | 0.83 | TNK2 (0.46) | TNK2FGFR2FGFR1PIK3CAPIK3CB | |
| SCHEMBL400470 | 0.83 | TNK2 (0.46) | TNK2FGFR2FGFR1PIK3CAPIK3CB | |
| SCHEMBL23216701 | 0.83 | TNK2 (0.37) | TNK2FGFR2FGFR1PIK3CAPIK3CB | |
| SCHEMBL1567075 | 0.80 | TNK2 (0.53) | TNK2FGFR2FGFR1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-B1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARM INC (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2009143051-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |