Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949666 | 0.85 | SLC22A12 (0.53) | GFERFFAR1KDM4ELMNAMEN1 | |
| SCHEMBL12892584 | 0.85 | AR (0.54) | GFERFFAR1KDM4ELMNAMEN1 | |
| SCHEMBL14949665 | 0.83 | SLC22A12 (0.51) | GFERKDM4ELMNAMEN1KMT2A | |
| SCHEMBL13981779 | 0.80 | KDM4E (0.53) | FFAR1KDM4ELMNAALDH1A1HTT | |
| SCHEMBL1259881 | 0.78 | KDM4E (0.50) | GFERFFAR1KDM4ELMNAMEN1 | |
| SCHEMBL3644939 | 0.75 | ALDH1A1 (0.48) | KDM4ELMNAMEN1KMT2AMAPT | |
| SCHEMBL1471967 | 0.75 | FFAR1 (0.88) | GFERFFAR1LMNAMEN1KMT2A | |
| SCHEMBL31748788 | 0.75 | ALDH1A1 (0.82) | KDM4ELMNAKMT2AMAPTPOLB | |
| SCHEMBL3486122 | 0.75 | ALDH1A1 (0.82) | KDM4ELMNAKMT2AMAPTPOLB | |
| SCHEMBL3643634 | 0.75 | MAPT (0.48) | KDM4ELMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |