SCHEMBL4315225

SCHEMBL4315225

N=C(N)c1ccc2nc(-c3ccccc3O)[nH]c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F2 P00734 14/20 1.00
F10 P00742 14/20 1.00
PLAU P00749 14/20 1.00
PRSS1 P07477 14/20 1.00
PLG P00747 13/20 1.00
PLAT P00750 12/20 1.00
HPN P05981 1/20 1.00
PRSS2 P07478 1/20 1.00
PRSS3 P35030 1/20 1.00
F9 P00740 1/20 0.72
F7 P08709 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4992404 0.89 F2 (0.81) F2F10PLAUPRSS1PLG
SCHEMBL30583190 0.89 F2 (0.81) F2F10PLAUPRSS1PLG
SCHEMBL7481346 0.88 F2 (0.86) F2F10PLAUPRSS1PLG
SCHEMBL29002011 0.86 F2 (0.76) F2F10PLAUPRSS1PLG
SCHEMBL6289543 0.86 F2 (0.76) F2F10PLAUPRSS1PLG
SCHEMBL29941983 0.84 F10 (1.00) F2F10PLAUPRSS1PLG
SCHEMBL6292957 0.84 F10 (1.00) F2F10PLAUPRSS1PLG
SCHEMBL29941478 0.83 F10 (1.00) F2F10PLAUPRSS1PLG
SCHEMBL5398313 0.83 PLAU (0.74) F2F10PLAUPRSS1PLG
Hydrochloric Acid SCHEMBL6355471 0.83 F2 (0.74) F2F10PLAUPRSS1PLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 EP disclosed
US-11573224-B2 Methods of detection using X-ray fluorescence ICAGEN, LLC (US) 2023-02-07 US disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-10877035-B2 Advanced drug development and manufacturing ICAGEN, LLC (US) 2020-12-29 US disclosed
US-20200278346-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ADJACENT ACQUISITION CO., LLC 2020-09-03 US disclosed
EP-3681504-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE Icagen, Inc. (US) 2020-07-22 EP disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 US disclosed
WO-2019055754-A1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN, INC. (US) 2019-03-21 WO disclosed
US-20150309021-A1 Advanced Drug Development and Manufacturing LOS ALAMOS NATIONAL SECURITY, LLC 2015-10-29 US disclosed
EP-2511844-B1 X-ray microscope XRPRO SCIENCES INC (US) 2015-08-12 EP disclosed
EP-2511844-A2 Advanced drug development and manufacturing Los Alamos National Security, LLC (US) 2012-10-17 EP disclosed
EP-2084519-B1 X-RAY FLUORESCENCE ANALYSIS METHOD LOS ALAMOS NAT SECURITY LLC (US) 2012-08-01 EP disclosed
EP-2084519-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING Los Alamos National Security, LLC (US) 2009-08-05 EP disclosed
WO-2008127291-A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING LOS ALAMOS NATIONAL SECURITY, LLC (US) 2008-10-23 WO disclosed
US-20080220441-A1 Advanced drug development and manufacturing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2008-09-11 US disclosed