Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Perhexiline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT2 known ✓ | P23786 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | MLNR | O43193 | 1/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.80 |
| ▸ | EGFR | P00533 | 1/20 | 0.80 |
| ▸ | FYN | P06241 | 1/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perhexiline SCHEMBL15516137 | 0.89 | CYP2D6 (1.00) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL114894 | 0.89 | CYP2D6 (1.00) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL145849 | 0.89 | CYP2D6 (1.00) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL13417497 | 0.89 | CYP2D6 (1.00) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL29089418 | 0.88 | CYP2D6 (0.96) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL28885519 | 0.88 | CYP2D6 (0.96) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL4831305 | 0.88 | CYP2D6 (0.96) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL11451421 | 0.87 | LMNA (0.80) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL16237937 | 0.84 | CYP2D6 (0.89) | CYP2D6MEN1LMNATP53KMT2A | |
| Perhexiline SCHEMBL123149 | 0.84 | MEN1 (1.00) | CYP2D6MEN1LMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10877035-B2 | Advanced drug development and manufacturing | ICAGEN, LLC (US) | 2020-12-29 | — | — | US | disclosed |
| US-20150309021-A1 | Advanced Drug Development and Manufacturing | LOS ALAMOS NATIONAL SECURITY, LLC | 2015-10-29 | — | — | US | disclosed |
| EP-2511844-B1 | X-ray microscope | XRPRO SCIENCES INC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2084519-B1 | X-RAY FLUORESCENCE ANALYSIS METHOD | LOS ALAMOS NAT SECURITY LLC (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2084519-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | Los Alamos National Security, LLC (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008127291-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2008-10-23 | — | — | WO | disclosed |