Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 16/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639609 | 0.88 | CCR1 (0.40) | CCR1BRD4ALDH1A1SUV39H2CYP2C19 | |
| SCHEMBL3636906 | 0.87 | CCR1 (0.42) | CCR1ALDH1A1 | |
| SCHEMBL4694944 | 0.86 | CCR1 (0.41) | CCR1BRD4SUV39H2 | |
| SCHEMBL3637368 | 0.84 | CCR1 (0.41) | CCR1SUV39H2CYP2C19KCNH2 | |
| SCHEMBL3632624 | 0.83 | CCR1 (0.43) | CCR1CYP2C19KCNH2 | |
| SCHEMBL3633474 | 0.82 | CCR1 (0.40) | CCR1BRD4ALDH1A1CYP2C19KCNH2 | |
| SCHEMBL3631827 | 0.81 | CCR1 (0.39) | CCR1BRD4ALDH1A1CYP2C19KCNH2 | |
| SCHEMBL4016485 | 0.81 | CCR1 (0.60) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4310454 | 0.80 | CCR1 (0.43) | CCR1BRD4ALDH1A1SUV39H2 | |
| SCHEMBL4692528 | 0.79 | CCR1 (0.40) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |