Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4323096 | 0.74 | MAPT (0.33) | LMNAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL1259639 | 0.73 | SLC22A12 (0.47) | SLC22A12ARSCN9AKDM4ELMNA | |
| SCHEMBL12892592 | 0.72 | AR (0.48) | SLC22A12ARSCN9AKDM4ELMNA | |
| SCHEMBL1259881 | 0.71 | KDM4E (0.50) | ARKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL1260264 | 0.71 | KDM4E (0.46) | SLC22A12ARKDM4ELMNAHTT | |
| SCHEMBL14949666 | 0.70 | SLC22A12 (0.53) | SLC22A12KDM4ELMNAFFAR1MEN1 | |
| SCHEMBL12892584 | 0.70 | AR (0.54) | ARKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL12892599 | 0.70 | CYP2C9 (0.46) | SLC22A12ARKDM4ELMNAHTT | |
| SCHEMBL13981779 | 0.68 | KDM4E (0.53) | SLC22A12KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL4314968 | 0.68 | GFER (0.58) | SLC22A12KDM4ELMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |