Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phthalimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.71 |
| ▸ | CASP3 | P42574 | 4/20 | 0.60 |
| ▸ | CASP2 | P42575 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalimide SCHEMBL11492689 | 0.98 | GSK3B (0.68) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL1132405 | 0.93 | GSK3B (0.75) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL15488735 | 0.90 | GSK3B (0.79) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL10544624 | 0.88 | GSK3B (0.68) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL10495304 | 0.88 | GSK3B (0.56) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL7297919 | 0.88 | GSK3B (0.75) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL3984602 | 0.87 | GSK3B (0.94) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL34465463 | 0.87 | GSK3B (0.60) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL30452542 | 0.86 | GSK3B (0.71) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL23063638 | 0.85 | GSK3B (0.88) | GSK3BCASP3CASP2CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116769253-B | Geogrid modified polypropylene engineering plastic and preparation method and application thereof | 山东路德新材料股份有限公司 | 2023-12-12 | — | — | CN | claimed |
| CN-117024878-A | Modified polypropylene geogrid raw material and geogrid | 山东路德新材料股份有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-116769253-A | Geogrid modified polypropylene engineering plastic and preparation method and application thereof | 山东路德新材料股份有限公司 | 2023-09-19 | — | — | CN | claimed |
| CN-113372256-A | Synthesis method of N-phthalimidoacetic acid | 仪征市海帆化工有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-108070279-B | Pigment dispersion and coloring composition using phthalimide and derivative thereof | 山阳色素株式会社 | 2021-09-07 | — | — | CN | claimed |
| CN-111153461-A | Method for treating europium-containing wastewater by using chelate resin | 东华理工大学 | 2020-05-15 | — | — | CN | claimed |
| CN-102815765-B | Deep softening method for thick oil sewage | PETROCHINA CO LTD | 2014-04-02 | — | — | CN | claimed |
| CN-102827393-B | Synthetic method of chelate adsorption resin suitable for heavy oil sewage | PETROCHINA CO LTD | 2014-02-19 | — | — | CN | claimed |
| CN-102827393-A | Synthetic method of chelate adsorption resin suitable for heavy oil sewage | PETROCHINA CO LTD | 2012-12-19 | — | — | CN | claimed |
| CN-102815765-A | Deep softening method for thick oil sewage | CHINA NAT PETROLEUM CORP | 2012-12-12 | — | — | CN | claimed |
| CN-117402155-B | Electrolyte additive containing thiadiazole structure, preparation method thereof, electrolyte and lithium ion battery | 蓝固(淄博)新能源科技有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-117402155-A | Electrolyte additive containing thiadiazole structure, preparation method thereof, electrolyte and lithium ion battery | 蓝固(淄博)新能源科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116769253-B | Geogrid modified polypropylene engineering plastic and preparation method and application thereof | 山东路德新材料股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-117024878-A | Modified polypropylene geogrid raw material and geogrid | 山东路德新材料股份有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-117043255-A | Polypropylene composition for cable insulation | 博里利斯股份公司 | 2023-11-10 | — | — | CN | disclosed |
| US-4257947-A | INTERMEDIATES FOR ANTIBACTERIAL CEPHALOSPORINS | SMITHKLINE CORPORATION (US) | 1981-03-24 | — | — | US | disclosed |
| US-4166816-A | CYCLIZATION | SMITHKLINE CORPORATION (US) | 1979-09-04 | — | — | US | disclosed |
| US-4162250-A | INTERMEDIATES FOR BACTERICIDES | SMITHKLINE CORPORATION (US) | 1979-07-24 | — | — | US | disclosed |
| US-4103086-A | 8-Oxo-4-thia-1-azabicyclo (4.2.0)-oct-2-ene derivatives | SMITHKLINE CORPORATION (US) | 1978-07-25 | — | — | US | disclosed |
| US-4072674-A | FOR CEPHALOSPORIN CONGENERS | SMITHKLINE CORPORATION (US) | 1978-02-07 | — | — | US | disclosed |