Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 1.00 |
| ▸ | DPP7 | Q9UHL4 | 18/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 15/20 | 1.00 |
| ▸ | DPP9 | Q86TI2 | 14/20 | 1.00 |
| ▸ | FAP | Q12884 | 13/20 | 1.00 |
| ▸ | PITRM1 | Q5JRX3 | 5/20 | 1.00 |
| ▸ | PREP | P48147 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Talabostat SCHEMBL14160935 | 1.00 | DPP4 (1.00) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL14160999 | 1.00 | DPP4 (1.00) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL21156686 | 1.00 | DPP4 (1.00) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL6895250 | 1.00 | DPP4 (1.00) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL14160998 | 1.00 | DPP4 (1.00) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL393024 | 1.00 | DPP4 (1.00) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL12185345 | 1.00 | DPP4 (1.00) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL23070729 | 0.93 | DPP4 (0.86) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL7417653 | 0.93 | DPP4 (0.86) | DPP4DPP7DPP8DPP9FAP | |
| Talabostat SCHEMBL4782073 | 0.93 | DPP4 (0.86) | DPP4DPP7DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960127-B1 | ISOLATED DIMERIC FIBROBLAST ACTIVATION PROTEIN ALPHA, AND USES THEREOF | LUDWIG INST CANCER RES (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008066729-A2 | BORONIC ACID CONTAINING COMPOSITIONS | DARA BIOSCIENCES, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| EP-0960127-A4 | ISOLATED DIMERIC FIBROBLAST ACTIVATION PROTEIN ALPHA, AND USES THEREOF | LUDWIG INST CANCER RES (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-0960127-A1 | ISOLATED DIMERIC FIBROBLAST ACTIVATION PROTEIN ALPHA, AND USES THEREOF | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1997034927-A1 | ISOLATED DIMERIC FIBROBLAST ACTIVATION PROTEIN ALPHA, AND USES THEREOF | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 1997-09-25 | — | — | WO | disclosed |