Talabostat

Talabostat

SCHEMBL21156686

CC(C)C(N)C(=O)N1CCC[C@H]1B(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 1.00
DPP7 Q9UHL4 18/20 1.00
DPP8 Q6V1X1 15/20 1.00
DPP9 Q86TI2 14/20 1.00
FAP Q12884 13/20 1.00
PITRM1 Q5JRX3 5/20 1.00
PREP P48147 4/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Talabostat SCHEMBL14160935 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL14160999 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL6895250 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL14160998 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL393024 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL12185345 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL4320843 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL23070729 0.93 DPP4 (0.86) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL7417653 0.93 DPP4 (0.86) DPP4DPP7DPP8DPP9FAP
Talabostat SCHEMBL4782073 0.93 DPP4 (0.86) DPP4DPP7DPP8DPP9FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES THE SCRIPPS RESEARCH INSTITUTE 2024-04-11 US claimed
US-20240207292-A1 BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS TRUSTEES OF TUFTS COLLEGE 2024-06-27 US disclosed
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES THE SCRIPPS RESEARCH INSTITUTE 2024-04-11 US disclosed
US-20230372372-A1 COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS TRUSTEES OF TUFTS COLLEGE 2023-11-23 US disclosed
US-20230338402-A1 TREATMENT REGIMEN FOR CANCER USING IMMUNOMODULATION OAKTREE FUND ADMINISTRATION, LLC 2023-10-26 US disclosed
US-20230330275-A1 FAP-TARGETED RADIOPHARMACEUTICALS AND IMAGING AGENTS, AND USES RELATED THERETO TRUSTEES OF TUFTS COLLEGE 2023-10-19 US disclosed
WO-2023172958-A1 STABLE FORMULATIONS OF TALABOSTAT ONKOSXCEL THERAPEUTICS, LLC (US) 2023-09-14 WO disclosed
US-20230258645-A1 ANTXR1 AS A BIOMARKER OF IMMUNOSUPPRESSIVE FIBROBLAST POPULATIONS AND ITS USE FOR PREDICTING RESPONSE TO IMMUNOTHERAPY INSTITUT CURIE (FR) 2023-08-17 US disclosed
US-11707539-B2 FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto TRUSTEES OF TUFTS COLLEGE (US) 2023-07-25 US disclosed
US-11583516-B2 Dash inhibitors, and uses related thereto TRUSTEES OF TUFTS COLLEGE (US) 2023-02-21 US disclosed
US-11559537-B2 Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists TRUSTEES OF TUFTS COLLEGE (US) 2023-01-24 US disclosed
US-20220257759-A1 TREATMENT OF SARCOMA USING IMMUNOMODULATION OAKTREE FUND ADMINISTRATION, LLC 2022-08-18 US disclosed
US-20200054655-A1 COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS TRUSTEES OF TUFTS COLLEGE 2020-02-20 US disclosed
US-20190209525-A1 DASH INHIBITORS, AND USES RELATED THERETO TRUSTEES OF TUFTS COLLEGE 2019-07-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230330275-A1 FAP-TARGETED RADIOPHARMACEUTICALS AND IMAGING AGENTS, AND USES RELATED THERETO FAP, APC, FIBP DPP4 147/4885DPP7 145/4885DPP8 223/4885
US-11583516-B2 Dash inhibitors, and uses related thereto PCNA, CD2BP2, CCNO DPP4 421/4885DPP7 130/4885DPP8 92/4885
US-11559537-B2 Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists CASP1, CASP2, APAF1 DPP4 1251/4885DPP7 910/4885DPP8 904/4885
US-20230372372-A1 COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS CASP1, CASP2, APAF1 DPP4 1251/4885DPP7 910/4885DPP8 904/4885
US-11707539-B2 FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto FAP, APC, FIBP DPP4 147/4885DPP7 145/4885DPP8 223/4885
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES DPP4, DPP7, ING2 DPP4 1/4885DPP7 2/4885DPP8 8/4885
US-20240207292-A1 BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS BCL6B, BCL6, BTD DPP4 3953/4885DPP7 4114/4885DPP8 3921/4885
US-20200054655-A1 COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS CASP1, CASP2, APAF1 DPP4 1251/4885DPP7 910/4885DPP8 904/4885
US-20190209525-A1 DASH INHIBITORS, AND USES RELATED THERETO CD2BP2, PCNA, CD2 DPP4 402/4885DPP7 127/4885DPP8 94/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.