Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | INSR | P06213 | 5/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896630 | 0.95 | INSR (0.40) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL1894442 | 0.93 | IGF1R (0.39) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL1891769 | 0.92 | INSR (0.39) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL1894802 | 0.91 | IGF1R (0.38) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL4326750 | 0.89 | IGF1R (0.41) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL4316899 | 0.86 | IGF1R (0.57) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL1433425 | 0.85 | INSR (0.42) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL1433424 | 0.85 | INSR (0.42) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL1893910 | 0.85 | INSR (0.42) | IGF1RINSRALKAURKAAURKB | |
| SCHEMBL4323676 | 0.85 | IGF1R (0.40) | IGF1RINSRALKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138440-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-19 | — | — | WO | claimed |
| WO-2009138440-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-19 | — | — | WO | disclosed |