Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.55 |
| ▸ | MTOR | P42345 | 4/20 | 0.55 |
| ▸ | ABCC2 | Q92887 | 13/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1429293 | 1.00 | PIK3CA (0.55) | PIK3CAMTORABCC2PIK3CGTYR | |
| SCHEMBL4322948 | 0.92 | ABCC2 (0.56) | PIK3CAMTORABCC2PIK3CGTYR | |
| SCHEMBL1428396 | 0.92 | PIK3CA (0.53) | PIK3CAMTORABCC2PIK3CGTYR | |
| SCHEMBL1429395 | 0.92 | ABCC2 (0.56) | PIK3CAMTORABCC2PIK3CGTYR | |
| SCHEMBL4320453 | 0.92 | PIK3CA (0.53) | PIK3CAMTORABCC2PIK3CGTYR | |
| SCHEMBL4319912 | 0.88 | ABCC2 (0.70) | PIK3CAMTORABCC2PIK3CG | |
| SCHEMBL1428711 | 0.88 | ABCC2 (0.70) | PIK3CAMTORABCC2PIK3CG | |
| SCHEMBL1428864 | 0.84 | ABCC2 (0.57) | PIK3CAMTORABCC2PIK3CG | |
| SCHEMBL4324018 | 0.84 | ABCC2 (0.57) | PIK3CAMTORABCC2PIK3CG | |
| SCHEMBL1429524 | 0.82 | ABCC2 (0.64) | PIK3CAMTORABCC2PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | claimed |
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PDPK1 | PIK3CA 4/4885MTOR 1/4885ABCC2 4452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.