Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | NOS1 | P29475 | 9/20 | 0.72 |
| ▸ | NOS3 | P29474 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | DDAH1 | O94760 | 6/20 | 0.68 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL30679324 | 1.00 | NOS2 (1.00) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL30577923 | 1.00 | NOS2 (1.00) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL30631154 | 1.00 | NOS2 (1.00) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL288993 | 1.00 | NOS2 (1.00) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL288835 | 1.00 | NOS2 (1.00) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL31547986 | 0.98 | NOS2 (0.96) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL30074239 | 0.98 | NOS2 (0.96) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL29361849 | 0.98 | NOS2 (0.96) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL15152867 | 0.96 | NOS2 (0.92) | NOS2CYP2C19CYP1A2TSHRGLA | |
| Arginine SCHEMBL1532506 | 0.96 | NOS2 (0.92) | NOS2CYP2C19CYP1A2TSHRGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7260 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122070294-A | Stable vitreous material based on histidine, arginine and glutamic acid amino acids | 阵序补丁有限公司 | 2026-05-19 | — | — | CN | claimed |
| WO-2026099533-A1 | TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) WITH GPBP1 INHIBITORS | UNIVERSITAT DE VALÈNCIA (ES) | 2026-05-15 | — | — | WO | claimed |
| US-12616760-B2 | Synthetic cyclic peptide mimetics | BAR ILAN UNIVERSITY (IL) | 2026-05-05 | — | — | US | claimed |
| US-12616761-B2 | CXCR4-targeting compounds | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2026-05-05 | — | — | US | claimed |
| EP-4696699-A1 | ? OPIOID RECEPTOR AGONIST AND USE THEREOF | Chengdu Aoda Biotechnology Co., Ltd. (CN) | 2026-02-18 | — | — | EP | claimed |
| EP-4696700-A1 | LONG-ACTING K-OPIOID RECEPTOR AGONIST | Chengdu Aoda Biotechnology Co., Ltd (CN) | 2026-02-18 | — | — | EP | claimed |
| US-12556566-B2 | Systems and methods for dynamic vulnerability scoring | SECUREWORKS CORP. (US) | 2026-02-17 | — | — | US | claimed |
| US-20260007731-A1 | INTRANASAL POLYSACCHARIDE CONJUGATE NANOMULSION VACCINES AND METHODS OF USING THE SAME | BLUEWILLOW BIOLOGICS, INC. (US) | 2026-01-08 | — | — | US | claimed |
| EP-3528787-B1 | PHARMACEUTICAL FORMULATIONS AND METHODS OF MAKING THE SAME | AMGEN INC (US) | 2026-01-07 | — | — | EP | claimed |
| US-20260001915-A1 | METHODS FOR TREATING OBESITY WITH AN MC4R AGONIST | RHYTHM PHARMACEUTICALS INC (US) | 2026-01-01 | — | — | US | claimed |
| EP-0037246-B1 | POLYPEPTIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-03-07 | — | — | EP | claimed |
| US-4399125-A | CYCLIC OLIGOPEPTIDES | TRUSTEES OF COLUMBIA UNIVERSITY THE, A CORP. OF NY. | 1983-08-16 | — | — | US | claimed |
| EP-0082648-A2 | Cephalosporin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-29 | — | — | EP | claimed |
| EP-0078703-A2 | New tagged pyroglu-l-phe-l-arg derivatives, substrates and assays for kallikrein | UNIVERSITY OF MIAMI (US) | 1983-05-11 | — | — | EP | claimed |
| EP-0015036-B1 | PSYCHO-PHARMACOLOGICAL PEPTIDES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL COMPOSITIONS CONTAINING THEM | AKZO N.V. (NL) | 1983-05-04 | — | — | EP | claimed |
| US-4367225-A | Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | THE MEDICAL COLLEGE OF OHIO (US) | 1983-01-04 | — | — | US | claimed |
| EP-0061356-A2 | Antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | Medical College of Ohio (US) | 1982-09-29 | — | — | EP | claimed |
| US-4309340-A | INDUCTORS OF DIFFERENTIATION OF T-LYMPHOCYTES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-01-05 | — | — | US | claimed |
| EP-0037246-A2 | Polypeptides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-10-07 | — | — | EP | claimed |
| US-4271152-A | FRAGMENTS OF B-LIPOTROPIN | AKZO N.V. (NL) | 1981-06-02 | — | — | US | claimed |