Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.52 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.50 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082319 | 0.85 | HIF1A (0.52) | HIF1AMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13475954 | 0.81 | TLR7 (0.53) | HIF1AMAPTMEN1KMT2AHPGD | |
| Dibenzoylmethane SCHEMBL28976284 | 0.76 | MEN1 (0.94) | HIF1AMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL18844093 | 0.75 | MEN1 (0.68) | HIF1AMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL14982176 | 0.74 | MEN1 (0.55) | HIF1AMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL14014056 | 0.74 | TDP1 (0.66) | HIF1AMAPTMEN1KMT2AHPGD | |
| Dibenzoylmethane SCHEMBL39582 | 0.74 | MEN1 (1.00) | HIF1AMAPTMEN1KMT2ACYP3A4 | |
| Dibenzoylmethane SCHEMBL10356288 | 0.74 | MEN1 (1.00) | HIF1AMAPTMEN1KMT2ACYP3A4 | |
| Dibenzoylmethane SCHEMBL1704711 | 0.74 | MEN1 (1.00) | HIF1AMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL2643079 | 0.73 | RAB9A (0.47) | HIF1AMAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569688-B2 | Propane-1, 3-dione derivative | ASTELLAS PHARMA INC. (JP) | 2009-08-04 | — | — | US | disclosed |
| EP-1300398-B1 | PROPANE-1,3-DIONE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2006-04-05 | — | — | EP | disclosed |
| US-20050267110-A1 | Propane-1, 3-dione derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. | 2005-12-01 | — | — | US | disclosed |
| US-6960591-B2 | Propane-1,3-dione derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-20030191164-A1 | Propane-1,3-dione derivatives | ASTELLAS PHARMA INC. (JP) | 2003-10-09 | — | — | US | disclosed |
| EP-1300398-A1 | PROPANE-1,3-DIONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191164-A1 | Propane-1,3-dione derivatives | GNRHR, GPER1, FSHR | HIF1A 979/4885MAPT 2864/4885MEN1 1312/4885 |
| US-20050267110-A1 | Propane-1, 3-dione derivative | GNRHR, GPER1, FSHR | HIF1A 988/4885MAPT 3016/4885MEN1 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.