Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KLK3 | P07288 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15885087 | 0.79 | KMT2A (0.56) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4452243 | 0.78 | KMT2A (0.47) | KMT2AMEN1SCN9ASCN4ANPC1 | |
| SCHEMBL2629325 | 0.77 | KMT2A (0.50) | KMT2AMEN1MKNK1MKNK2KEAP1 | |
| SCHEMBL28790901 | 0.75 | MAPK1 (0.54) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24378643 | 0.75 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2TP53KDM4E | |
| SCHEMBL939191 | 0.74 | JMJD6 (0.65) | KMT2AMKNK1MKNK2KEAP1NPC1 | |
| SCHEMBL23213539 | 0.74 | CYP1A2 (0.55) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10695393 | 0.74 | POLB (0.54) | KMT2ASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL24378642 | 0.74 | KCNH2 (0.58) | KMT2AIRAK4SCN4A | |
| SCHEMBL16963931 | 0.74 | KMT2A (0.50) | KMT2AKEAP1SCN4AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153636-B | Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors | 朱比连特埃皮科尔有限责任公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2009090548-A2 | 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-23 | — | — | WO | disclosed |