Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.80 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702803 | 0.89 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL29993300 | 0.89 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL28348654 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| Sch-351591 SCHEMBL29378661 | 0.82 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL8290205 | 0.82 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| Sch-351591 SCHEMBL157018 | 0.82 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL432864 | 0.81 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7982331 | 0.80 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7982349 | 0.80 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL13035036 | 0.79 | PDE4B (0.71) | PDE4APDE4BPDE4CPDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931713-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES FAVOURED BY INSUFFICIENT MUCOSAL HYDRATION | Parion Sciences, Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| EP-2855435-A2 | DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES | Parion Sciences, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| EP-2755708-A2 | INHALER | Astrazeneca AB (SE) | 2014-07-23 | — | — | EP | disclosed |
| EP-2755707-A1 | INHALER | Astrazeneca AB (SE) | 2014-07-23 | — | — | EP | disclosed |
| WO-2014099676-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES FAVOURED BY INSUFFICIENT MUCOSAL HYDRATION | PARION SCIENCES, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2013181232-A2 | DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES | JOHNSON MICHAEL ROSS (US) | 2013-12-05 | — | — | WO | disclosed |
| EP-2595684-A1 | INHALER | AstraZeneca AB (SE) | 2013-05-29 | — | — | EP | disclosed |
| EP-2595683-A2 | INHALER | AstraZeneca AB (SE) | 2013-05-29 | — | — | EP | disclosed |
| WO-2013038169-A1 | INHALER | ASTRAZENECA AB (SE) | 2013-03-21 | — | — | WO | disclosed |
| WO-2013038170-A2 | INHALER | ASTRAZENECA AB (SE) | 2013-03-21 | — | — | WO | disclosed |
| WO-2010042036-A1 | INHALER WITH AUDIBLE INDICATOR MEANS | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | WO | disclosed |
| WO-2009154562-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A 4-HYDROXY-2-OXO-2, 3- DIHYDRO-1, 3-BENZOTHIAZOL-7-YL COMPOUND FOR MODULATION OF BETA2-ADRENORECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009152171-A1 | CORTICOSTEROID LINKED BETA-AGONIST COMPOUNDS FOR USE IN THERAPY | GILEAD SCIENCES, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
| EP-2117542-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | AstraZeneca AB (SE) | 2009-11-18 | — | — | EP | disclosed |
| WO-2009037503-A2 | NEW COMBINATION - 012 FOR THE TREATMENT OF RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2009-03-26 | — | — | WO | disclosed |
| WO-2008104776-A1 | COMBINATIONS OF BETA-2-ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008096111-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008096121-A1 | COMBINATIONS OF BETA-2-ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | WO | disclosed |
| EP-1888033-A2 | METHOD AND COMPOSITION FOR TREATING INFLAMMATORY DISORDERS | Biolipox AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006131737-A2 | METHOD AND COMPOSITION FOR TREATING INFLAMMATORY DISORDERS | BIOLIPOX AB (SE) | 2006-12-14 | — | — | WO | disclosed |