Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.80 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sch-351591 SCHEMBL157018 | 0.92 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| Sch-351591 SCHEMBL29378661 | 0.92 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL29993300 | 0.89 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL4702803 | 0.89 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL13035036 | 0.86 | PDE4B (0.71) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7982349 | 0.84 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7982331 | 0.84 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL432864 | 0.82 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7982313 | 0.82 | PDE4B (0.70) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL434601 | 0.82 | PDE4B (0.70) | PDE4APDE4BPDE4CPDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005028471-A1 | SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS | SCHERING CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |