Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Ethylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL6916211 | 0.77 | BRD4 (0.44) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL9440349 | 0.75 | BRD4 (0.44) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL10592962 | 0.75 | BRD4 (0.44) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL9778190 | 0.74 | BRD4 (0.41) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL7545965 | 0.73 | BRD4 (0.47) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL16144796 | 0.73 | BRD4 (0.43) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL28344074 | 0.73 | BRD4 (0.45) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL6940606 | 0.71 | BRD4 (0.44) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL9074416 | 0.71 | HDAC3 (0.48) | BRD4HDAC3HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL9440346 | 0.71 | BRD4 (0.44) | BRD4HDAC3HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592403-B2 | Ethylene polymer, preparation process thereof and molded articles of the same | MITSUI CHEMICALS, INC. (JP) | 2009-09-22 | — | — | US | claimed |
| US-7592403-B2 | Ethylene polymer, preparation process thereof and molded articles of the same | MITSUI CHEMICALS, INC. (JP) | 2009-09-22 | — | — | US | disclosed |
| US-20050267273-A1 | Ethylene polymer, preparation process thereof and molded articles of the same | MITSUI CHEMICALS, INC. | 2005-12-01 | — | — | US | disclosed |
| EP-1231229-A2 | Ethylene polymer, preparation process thereof and molded articles of the same | Mitsui Chemicals, Inc. (JP) | 2002-08-14 | — | — | EP | disclosed |
| US-20020107343-A1 | Ethylene polymer, preparation process thereof and molded articles of the same | MITSUI CHEMICALS, INC. | 2002-08-08 | — | — | US | disclosed |