Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 8/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 7/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.36 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.36 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.36 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.36 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325897 | 0.88 | LCK (0.42) | PARP1ALOX5APPLA2G2APLA2G10SLCO1B1 | |
| SCHEMBL4316571 | 0.85 | PIK3CD (0.43) | PARP1PLA2G2APLA2G10SLCO1B1HSP90AA1 | |
| SCHEMBL4331599 | 0.84 | PARP1 (0.40) | PARP1PLA2G2APLA2G10GRM2 | |
| SCHEMBL13571399 | 0.73 | HTT (0.50) | PARP1PLA2G2APLA2G10JAK3 | |
| SCHEMBL4331608 | 0.72 | PIK3CD (0.40) | GRM2 | |
| SCHEMBL4325889 | 0.72 | CHEK2 (0.40) | PARP1LCKKDRJAK3MAPK14 | |
| SCHEMBL5498386 | 0.71 | MAP4K1 (0.50) | ALOX5APFEN1LCKKDRJAK3 | |
| SCHEMBL27837954 | 0.69 | PLA2G2A (0.47) | PARP1FEN1PLA2G2APLA2G10SLCO1B1 | |
| SCHEMBL4325902 | 0.69 | PIK3CD (0.41) | — | |
| SCHEMBL4316563 | 0.68 | PIK3CD (0.43) | PARP1PLA2G2APLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069320-A1 | Substituted 4-Amino-Quinazoline Compounds with Metabotropic Glutamate Receptor Regulating Activity and Uses Thereof | GRUENENTHAL GMBH (DE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069320-A1 | Substituted 4-Amino-Quinazoline Compounds with Metabotropic Glutamate Receptor Regulating Activity and Uses Thereof | GRM1, GRIN1, GRM2 | PARP1 4537/4885ALOX5AP 2326/4885FEN1 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.