Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860267 | 0.86 | SLC18A3 (0.47) | — | |
| SCHEMBL1864836 | 0.79 | CYP17A1 (0.41) | — | |
| SCHEMBL23728301 | 0.78 | ALDH1A1 (0.42) | JAK3HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL23728304 | 0.75 | HDAC3 (0.41) | JAK3HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL30520105 | 0.74 | JAK3 (0.76) | JAK3 | |
| SCHEMBL13505339 | 0.74 | JAK3 (0.76) | JAK3 | |
| SCHEMBL27091789 | 0.74 | HDAC8 (0.55) | JAK3HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL27870951 | 0.73 | JAK3 (0.65) | JAK3 | |
| SCHEMBL23728188 | 0.73 | ALDH1A1 (0.46) | JAK3HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL23728280 | 0.73 | HDAC3 (0.42) | JAK3HDAC3HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021335-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124316-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |