Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.48 |
| ▸ | CHRNA10 | Q9GZZ6 | 4/20 | 0.48 |
| ▸ | CHRNA9 | Q9UGM1 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5295848 | 0.98 | CHRNA7 (0.50) | CHRNA7CHRNA10CHRNA9MAOAMAOB | |
| SCHEMBL5305181 | 0.79 | CHRNA7 (0.56) | CHRNA7CHRNA10CHRNA9MAOAMAOB | |
| SCHEMBL562670 | 0.76 | CHRNA7 (0.62) | CHRNA7CHRNA10CHRNA9HTTKDM4E | |
| SCHEMBL19601077 | 0.76 | CHRNA7 (0.37) | CHRNA7CHRNA10CHRNA9MAOAMAOB | |
| Water SCHEMBL31247957 | 0.74 | CHRNA7 (0.67) | CHRNA7CHRNA10CHRNA9HTT | |
| SCHEMBL12533275 | 0.74 | CHRNA7 (0.67) | CHRNA7CHRNA10CHRNA9HTT | |
| Bromide SCHEMBL26093356 | 0.74 | CHRNA7 (0.67) | CHRNA7CHRNA10CHRNA9HTT | |
| Bromide SCHEMBL26093360 | 0.74 | CHRNA7 (0.70) | CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL4404023 | 0.74 | CHRNA7 (0.67) | CHRNA7CHRNA10CHRNA9HTT | |
| Hydrochloric Acid SCHEMBL1533941 | 0.74 | CHRNA7 (0.61) | CHRNA7CHRNA10CHRNA9HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629491-B2 | Hydrocarboxylation process | EASTMAN CHEMICAL COMPANY (US) | 2009-12-08 | — | — | US | disclosed |
| US-20070299280-A1 | forming propionic acid from ethylene, water and carbon monoxide; not using the hazardous and corrosive hydrogen halides or sulfonic acids; free of hydrogen iodide and/or ethyl iodide; no diethyl ketone by-products | EASTMAN CHEMICAL COMPANY (US) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299280-A1 | forming propionic acid from ethylene, water and carbon monoxide; not using the hazardous and corrosive hydrogen halides or sulfonic acids; free of hydrogen iodide and/or ethyl iodide; no diethyl ketone by-products | ETV6, ETV1, HAO2 | CHRNA7 1087/4885CHRNA10 2517/4885CHRNA9 2079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.