HAO2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL23147812	0.64	1/20
SCHEMBL28310139	0.62	1/20
SCHEMBL30078174	0.55	1/20
SCHEMBL23147510	0.55	1/20
SCHEMBL29812266	0.55	1/20
SCHEMBL27658275	0.54	1/20
SCHEMBL4964605	0.53	1/20
SCHEMBL6650228	0.53	1/20
SCHEMBL29812163	0.52	1/20
SCHEMBL4591235	0.51	1/20
SCHEMBL5255490	0.49	1/20
SCHEMBL23780336	0.49	1/20
SCHEMBL20213984	0.49	1/20
SCHEMBL30829475	0.49	1/20
SCHEMBL4821126	0.48	1/20
Water (SCHEMBL5256024)	0.48	1/20
SCHEMBL23453745	0.47	1/20
SCHEMBL17633566	0.47	1/20
SCHEMBL16260565	0.47	1/20
SCHEMBL10227328	0.46	1/20

Clinical trials — most relevant to HAO2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria	PHASE3	COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Evaluation of Response to Use of Intravesical Ozone Gas in Interstitial Cystitis /Bladder Pain Syndrome	PHASE2	UNKNOWN
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease	PHASE1/PHASE2	COMPLETED
Ketones in Heart Failure - Effects on Cardiac Efficiency	PHASE2	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
In Vivo Assessment of Cellular Metabolism in Humans	PHASE1	COMPLETED
Carbon Monoxide to Prevent Lung Inflammation	PHASE1	COMPLETED
Humidified High Flow Nasal Cannula Versus Nasal Intermittent Positive Ventilation in Neonates	PHASE1	UNKNOWN
Effect of ORI-guided Oxygen Titration on Oxidative Stress in Rhinoplasty Surgery	nan	COMPLETED
Relationship Between Vascular Endothelial Dysfunction and Beat-to-beat Blood Pressure Variability in Patients With OSAS	nan	UNKNOWN
Mitochondrial Function of Immune Cells in Sepsis	nan	COMPLETED
Oxidative Stress Parameters, Trace Element and Quality of Life in Men Before and After Covid-19 Vaccines	nan	UNKNOWN
Prevalence of DAO (diamino Oxidase) Deficiency in Newborns	nan	COMPLETED
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics	nan	RECRUITING
Lung-protective Mechanical Ventilation for Abdominal Laparoscopic Surgeries	nan	COMPLETED
Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19	nan	UNKNOWN
Predictors of Outcome of Pediatric Renal Transplantation	nan	NOT_YET_RECRUITING
Multicenter Study of 18F-Labeled NY104 for PET/CT Imaging in Renal Cell Carcinoma	nan	RECRUITING
Non Invasive End Tidal Carbon Dioxide Monitoring During Moderate Sedation	nan	COMPLETED
Predictive and Prognostic Value of Cellular Dysoxia Markers After Cardiac Surgery With Extracorporeal Circulation	nan	COMPLETED
The Clinical Outcome of Ultra-low Oxygen Tension on Post Thawed Human Blastocyst	nan	UNKNOWN
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery	nan	COMPLETED
Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN	nan	COMPLETED
High Altitude Medical Research Expedition Himlung 2013 - a Study of Human Adaption to Hypoxia	nan	COMPLETED
Requirement for Leucine in Adults Over 60 Years	nan	COMPLETED
Correlation of ETCO2 to PaCO2 Measured by Sentri Nasal Cannula	nan	UNKNOWN
Evaluation of Indirect Measurement of Respiratory Quotient in Non-cardiac Major Surgery (The BAR Study)	nan	COMPLETED
Metabolic Fluid Responsiveness in Children	nan	RECRUITING
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a HAO2 binder may also engage these)

Protein	Name	Similarity
Q07523	—	0.999	Q07523 →
Q9NYQ2	—	0.998	Q9NYQ2 →
Q01KC2	—	0.998	Q01KC2 →
B8B8K5	—	0.998	B8B8K5 →
Q7FAS1	—	0.997	Q7FAS1 →
B1HZY7	—	0.994	B1HZY7 →
Q7XPR4	—	0.993	Q7XPR4 →
B8AUI3	—	0.993	B8AUI3 →
B8B7C5	—	0.992	B8B7C5 →
B0BNF9	—	0.992	B0BNF9 →
Q9WU19	—	0.992	Q9WU19 →
Q6YT73	—	0.992	Q6YT73 →
Q9LRS0	—	0.992	Q9LRS0 →
Q9LJH5	—	0.991	Q9LJH5 →
Q4ULD7	—	0.991	Q4ULD7 →
Q3ZBW2	—	0.991	Q3ZBW2 →
O49506	—	0.990	O49506 →
Q9LRR9	—	0.989	Q9LRR9 →
C2K1F0	—	0.989	C2K1F0 →
C3K053	—	0.988	C3K053 →
P46454	—	0.988	P46454 →
Q24JJ8	—	0.988	Q24JJ8 →
A7FJF0	—	0.988	A7FJF0 →
A9R623	—	0.988	A9R623 →
B2JZQ1	—	0.988	B2JZQ1 →
A4TKI4	—	0.988	A4TKI4 →
Q1CGZ1	—	0.988	Q1CGZ1 →
P20932	—	0.987	P20932 →
Q6G0J2	—	0.987	Q6G0J2 →
B0BTC7	—	0.987	B0BTC7 →