SCHEMBL4331776

SCHEMBL4331776

CC(C)c1ccc(CNC(=O)C2c3ccccc3C(=O)N2C2CCC(F)(F)CC2)cn1

nearest known ligand 0.65

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 13/20 0.65
KCNH2 Q12809 9/20 0.65
SCN5A Q14524 8/20 0.65
SMN1; SMN2 Q16637 1/20 0.57
FPR1 P21462 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
TDP1 Q9NUW8 1/20 0.45
KCNA5 P22460 1/20 0.44
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13579065 0.84 SCN9A (0.54) SCN9AKCNH2SCN5ASMN1; SMN2FPR1
SCHEMBL13579101 0.83 SCN9A (0.69) SCN9AKCNH2SCN5ASMN1; SMN2FPR1
SCHEMBL13577808 0.82 SCN9A (0.80) SCN9AKCNH2SCN5ASMN1; SMN2FPR1
SCHEMBL4321569 0.81 SCN9A (0.79) SCN9AKCNH2SCN5ASMN1; SMN2FPR1
SCHEMBL4325285 0.79 SCN9A (1.00) SCN9AKCNH2SCN5AKCNA5
SCHEMBL13579075 0.73 TDP1 (0.72) SCN9AKCNH2SCN5ASMN1; SMN2FPR1
SCHEMBL4318494 0.72 SCN9A (0.57) SCN9AKCNH2SCN5ASMN1; SMN2FPR1
SCHEMBL4457879 0.72 SCN9A (0.68) SCN9AKCNH2SCN5ASMN1; SMN2FPR1
SCHEMBL4334649 0.72 SCN9A (0.64) SCN9AKCNH2SCN5ATDP1KCNA5
SCHEMBL4334652 0.72 SCN9A (0.54) SCN9AKCNH2SCN5ATDP1KCNA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO claimed
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed