SCHEMBL4334652

SCHEMBL4334652

CC(CN1C(=O)c2ccccc2C1C(=O)NCc1ccc(OC2CCC(F)(F)CC2)nc1)c1ccccn1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 17/20 0.54
KCNH2 Q12809 12/20 0.52
TDP1 Q9NUW8 1/20 0.46
SCN5A Q14524 11/20 0.45
KCNQ2 O43526 1/20 0.44
KCNA5 P22460 1/20 0.44
SCN2A Q99250 1/20 0.44
PRMT5 O14744 1/20 0.42
WDR77 Q9BQA1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4334649 0.83 SCN9A (0.64) SCN9AKCNH2TDP1SCN5AKCNQ2
SCHEMBL3889098 0.79 SCN9A (0.69) SCN9AKCNH2TDP1SCN5AKCNQ2
SCHEMBL3890708 0.78 SCN9A (0.71) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL3889685 0.75 SCN9A (0.71) SCN9AKCNH2SCN5AKCNQ2KCNA5
SCHEMBL4331776 0.72 SCN9A (0.65) SCN9AKCNH2TDP1SCN5AKCNA5
SCHEMBL4337162 0.72 SCN9A (0.85) SCN9AKCNH2TDP1SCN5AKCNQ2
SCHEMBL13579101 0.71 SCN9A (0.69) SCN9AKCNH2SCN5A
SCHEMBL3890432 0.71 KCNA5 (0.46) SCN9AKCNH2TDP1SCN5AKCNA5
SCHEMBL3888107 0.71 MAPT (0.46) SCN9AKCNH2TDP1SCN5AKCNA5
SCHEMBL4325568 0.70 SCN9A (1.00) SCN9AKCNH2SCN5AKCNQ2KCNA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO claimed