Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606255 | 0.84 | HRH4 (0.73) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL606256 | 0.84 | HRH4 (0.73) | HRH4CHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL2498394 | 0.77 | HRH4 (0.68) | HRH4 | |
| Trifluoroacetic Acid SCHEMBL2498396 | 0.77 | HRH4 (0.68) | HRH4 | |
| SCHEMBL9215125 | 0.74 | CHRNB2 (0.54) | CHRNB2CHRNA4 | |
| SCHEMBL12193789 | 0.69 | HRH4 (1.00) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL604188 | 0.69 | HRH4 (1.00) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL604187 | 0.69 | HRH4 (1.00) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL23932550 | 0.69 | CHRNB2 (0.51) | CHRNB2CHRNA4 | |
| SCHEMBL30040849 | 0.69 | CHRNB2 (0.51) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040549-A2 | BENZOFURO-AND BENZOTHIENOPYRYIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-01 | — | — | EP | claimed |
| WO-2008008359-A2 | BENZOFURO-AND BENZOTHIENOPYRYIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | WO | claimed |