Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14822491 | 0.85 | KDM4E (0.45) | KMT2AKDM4EPOLBMAPTHCAR2 | |
| SCHEMBL20418 | 0.79 | KDM4E (0.70) | KMT2AKDM4EPOLBMAPTPDE4D | |
| SCHEMBL9216975 | 0.76 | HCAR2 (0.33) | KMT2AKDM4EPOLBMAPTHCAR2 | |
| SCHEMBL20911 | 0.76 | HCAR2 (0.43) | KMT2AKDM4EPOLBMAPTHCAR2 | |
| SCHEMBL6257457 | 0.73 | KDM4E (0.44) | KMT2AKDM4EPOLBMAPTHCAR2 | |
| SCHEMBL28351122 | 0.71 | PDE4D (0.36) | KMT2AHCAR2PDE4DDAOMEN1 | |
| SCHEMBL1663754 | 0.70 | PDE4D (0.59) | KMT2AKDM4EHCAR2PDE4DDAO | |
| SCHEMBL28319174 | 0.69 | POLB (0.44) | KMT2AKDM4EPOLBMAPTHCAR2 | |
| SCHEMBL27575758 | 0.69 | HCAR2 (0.61) | HCAR2PDE4DDAO | |
| SCHEMBL28350977 | 0.68 | HCAR2 (0.38) | KMT2AHCAR2PDE4DDAOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595962-A1 | PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS | SOLVAY SA (BE) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010692-A1 | PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS | SOLVAY SA (BE) | 2012-01-26 | — | — | WO | disclosed |