Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 5/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861573 | 0.74 | SRC (0.40) | DHODHCTRCSRCRIPK2AKR1C3 | |
| SCHEMBL4348179 | 0.70 | SRC (0.37) | SRCRIPK2EPHX1PIK3CDPIK3CA | |
| SCHEMBL2861275 | 0.67 | CA12 (0.50) | DHODHCTRCAKR1C3AKR1C2MEN1 | |
| SCHEMBL6426390 | 0.67 | SRC (0.38) | DHODHCTRCSRCRIPK2PIK3CD | |
| SCHEMBL2864469 | 0.62 | SRC (0.42) | DHODHSRCRIPK2AKR1C3AKR1C2 | |
| SCHEMBL16246887 | 0.61 | SRC (0.67) | SRCRIPK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL2862300 | 0.61 | MEN1 (0.47) | DHODHMEN1KMT2ACA12 | |
| SCHEMBL2855683 | 0.60 | SRC (0.40) | DHODHSRCRIPK2PIK3CDPIK3CA | |
| SCHEMBL6836496 | 0.59 | CTRC (0.62) | DHODHCTRCMEN1KMT2ACA12 | |
| SCHEMBL2855850 | 0.59 | MAP2K4 (0.59) | CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541376-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20050282880-A1 | Novel 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282880-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | DHODH 4329/4885CTRC 2417/4885SRC 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.