Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.38 |
| ▸ | CES1 | P23141 | 4/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4334548 | 1.00 | CES2 (0.38) | CES2CES1PBRM1CCNA2CDK2 | |
| SCHEMBL4323510 | 0.88 | CES2 (0.46) | CES2CES1KCNK3MEN1KMT2A | |
| SCHEMBL4315245 | 0.86 | CES2 (0.39) | CES2CES1KCNK3MEN1KMT2A | |
| SCHEMBL4315249 | 0.86 | CES2 (0.39) | CES2CES1KCNK3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4325850 | 0.85 | PBRM1 (0.41) | CES2CES1PBRM1CCNA2CDK2 | |
| SCHEMBL4334695 | 0.82 | UNG (0.36) | CES2CES1KCNK3MEN1KMT2A | |
| SCHEMBL4318712 | 0.82 | CES2 (0.36) | CES2CES1KCNK3MEN1KMT2A | |
| SCHEMBL4318711 | 0.82 | CES2 (0.36) | CES2CES1KCNK3MEN1KMT2A | |
| SCHEMBL4334703 | 0.82 | UNG (0.36) | CES2CES1KCNK3MEN1KMT2A | |
| SCHEMBL4328053 | 0.81 | CDK5 (0.36) | CES2CES1CCNA2CDK2KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569688-B2 | Propane-1, 3-dione derivative | ASTELLAS PHARMA INC. (JP) | 2009-08-04 | — | — | US | disclosed |
| EP-1300398-B1 | PROPANE-1,3-DIONE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2006-04-05 | — | — | EP | disclosed |
| US-20050267110-A1 | Propane-1, 3-dione derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. | 2005-12-01 | — | — | US | disclosed |
| US-6960591-B2 | Propane-1,3-dione derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-20030191164-A1 | Propane-1,3-dione derivatives | ASTELLAS PHARMA INC. (JP) | 2003-10-09 | — | — | US | disclosed |
| EP-1300398-A1 | PROPANE-1,3-DIONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191164-A1 | Propane-1,3-dione derivatives | GNRHR, GPER1, FSHR | CES2 3350/4885CES1 2486/4885PBRM1 3181/4885 |
| US-20050267110-A1 | Propane-1, 3-dione derivative | GNRHR, GPER1, FSHR | CES2 3441/4885CES1 2593/4885PBRM1 3156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.