Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4337029 | 0.93 | MAPK14 (0.57) | MAPK14HSP90AA1ROCK2ROCK1NPC1 | |
| SCHEMBL4343801 | 0.90 | MAPK14 (0.58) | MAPK14HSP90AA1ROCK2ROCK1NPC1 | |
| SCHEMBL1877374 | 0.90 | MAPK14 (0.68) | MAPK14HSP90AA1ROCK2ROCK1NPC1 | |
| SCHEMBL4330121 | 0.88 | MAPK14 (0.64) | MAPK14HSP90AA1NPC1MEN1KMT2A | |
| SCHEMBL4518699 | 0.84 | MAPK14 (0.58) | MAPK14HSP90AA1MAPK9MAPK10MAPK11 | |
| SCHEMBL4342438 | 0.84 | MAPK14 (0.60) | MAPK14HSP90AA1NPC1MAPK9MAPK10 | |
| SCHEMBL4470925 | 0.84 | MAPK14 (0.60) | MAPK14HSP90AA1ROCK2ROCK1MAPK9 | |
| SCHEMBL4525548 | 0.84 | MAPK14 (0.57) | MAPK14HSP90AA1MAPK9MAPK10MAPK11 | |
| SCHEMBL4336216 | 0.84 | MAPK14 (0.59) | MAPK14HSP90AA1ROCK2NPC1MAPK9 | |
| SCHEMBL4332759 | 0.83 | MAPK14 (0.61) | MAPK14HSP90AA1MAPK9MAPK10MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207203-B2 | Pyridylisoxazole derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-20090306145-A1 | Pyridylisoxazole Derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| EP-2036905-A1 | PYRIDYLISOXAZOLE DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306145-A1 | Pyridylisoxazole Derivatives | CNKSR1, MAPK1, MAPK3 | MAPK14 43/4885HSP90AA1 2550/4885ROCK2 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.