Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4334761 | 0.93 | MAPK14 (0.54) | MAPK14HSP90AA1ROCK2ROCK1NPC1 | |
| SCHEMBL4343801 | 0.91 | MAPK14 (0.58) | MAPK14HSP90AA1ROCK2ROCK1NPC1 | |
| SCHEMBL1883195 | 0.89 | MAPK14 (0.72) | MAPK14HSP90AA1ROCK2ROCK1NPC1 | |
| SCHEMBL4335478 | 0.87 | MAPK14 (0.68) | MAPK14HSP90AA1NPC1ALDH1A1GAA | |
| SCHEMBL4342438 | 0.87 | MAPK14 (0.60) | MAPK14HSP90AA1NPC1ALDH1A1MAPK9 | |
| SCHEMBL4470925 | 0.87 | MAPK14 (0.60) | MAPK14HSP90AA1ROCK2ROCK1GAA | |
| SCHEMBL4334555 | 0.86 | MAPK14 (0.65) | MAPK14HSP90AA1 | |
| SCHEMBL4339803 | 0.85 | MAPK14 (0.61) | MAPK14HSP90AA1ROCK2ROCK1MAPK9 | |
| SCHEMBL4336216 | 0.85 | MAPK14 (0.59) | MAPK14HSP90AA1ROCK2NPC1ALDH1A1 | |
| SCHEMBL4332759 | 0.85 | MAPK14 (0.61) | MAPK14HSP90AA1MAPK9MAPK10MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207203-B2 | Pyridylisoxazole derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-20090306145-A1 | Pyridylisoxazole Derivatives | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| EP-2036905-A1 | PYRIDYLISOXAZOLE DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306145-A1 | Pyridylisoxazole Derivatives | CNKSR1, MAPK1, MAPK3 | MAPK14 43/4885HSP90AA1 2550/4885ROCK2 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.